Which percentage of fat can orlistat block from entering circulation through the intestines?

Orlistat is a weight-loss medication that works as a lipase inhibitor, meaning it blocks the fat-digesting enzymes in the gastrointestinal tract. Specifically, orlistat inhibits gastric and pancreatic lipases, which are responsible for breaking down dietary fats into smaller components so that they can be absorbed through the intestinal walls. By inhibiting these enzymes, orlistat effectively prevents approximately 30% of the dietary fat consumed from being absorbed into the body and entering circulation.

This mechanism helps to reduce the caloric intake associated with fat consumption, supporting weight management efforts when used alongside a reduced-calorie diet. The specified percentage, which reflects the clinical efficacy of orlistat, is significant for understanding its role in weight control strategies. Understanding how orlistat influences nutrient absorption can help inform discussions about its use, efficacy, and the importance of comprehensive dietary planning when incorporating medications into weight-loss regimens.