What type of physical effect does orlistat primarily target?

Orlistat primarily targets fat absorption in the digestive system. It works by inhibiting the action of enzymes known as lipases, which are responsible for breaking down dietary fats into smaller molecules that can be absorbed by the intestines. By blocking these enzymes, orlistat reduces the amount of dietary fat that is absorbed into the bloodstream, leading to a decrease in caloric intake and weight loss over time. This mechanism is particularly effective for individuals who consume a high-fat diet, as it directly influences fat metabolism rather than affecting the absorption of proteins, carbohydrates, or vitamins. Understanding the selective action of orlistat is crucial for those considering it as a weight-loss aid, as it emphasizes the importance of dietary composition in conjunction with its use.