How does sibutramine contribute to weight loss?

Sibutramine contributes to weight loss primarily by enhancing satiety through the uptake of neurotransmitters. It functions as an appetite suppressant by inhibiting the reuptake of serotonin, norepinephrine, and dopamine in the brain. This action increases the levels of these neurotransmitters in the synaptic cleft, leading to an increased feeling of fullness and reduced hunger. By improving satiety, individuals are likely to consume fewer calories, which can lead to weight loss over time.

The focus on neurotransmitter levels is crucial because it helps explain how sibutramine impacts eating behavior, rather than directly affecting fat metabolism, blocking fat absorption, or increasing muscle mass, which are mechanisms not directly related to this medication's primary function.